Multicomponent Synthesis, Characterization of Novel Pyrimidine Derivatives with Anti-cancer Potential

Abstract: Background: Search for the better anti-cancer agents become central part many research teams as current drugs in use suffer lack of specificity to cancer targets. Design and development target specific increase potency safety drugs. Materials Methods: Current intends develop a novel series pyrimidine derivatives owing potential scaffold. In multicomponent reaction approach, 4,5-disubstituted pyrimidines (4) were synthesized from three component coupling substituted enamine (1), an orthoester (triethoxy methane) (2) ammonium acetate (3). oxidized corresponding aldehyde derivative (5) via Stephen synthetic process. Then coupled with various aromatic amines produce final imine (6a-6j). By using IR, 1H-NMR, mass spectral studies, all prepared characterized subjected activity evaluation by MTT Assay. Four cells (A 549 (lung), B16F10 (mouse skin melanoma), SiHA (cervical), MCF-7 (breast), one normal fibroblast (L929)] employed study derivatives. Results: The compounds produced moderate good yields proposed scheme synthesis. All displayed noticeable cytotoxicity against tested cell lines. Conclusion: evaluated lines susceptible newly derivative. These brand-new may be transformed into potent lead molecules. Keywords: Multicomponent synthesis, Pyrimidines, Anti-cancer,